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Article

Murine Wee1 plays a critical role in cell cycle regulation and pre-implantation stages of embryonic development.

International journal of biological sciences - 1 Jan 2006

Tominaga Yohei, Li Cuiling, Wang Rui-Hong, Deng Chu-Xia

Abstract excerpt

Wee1 kinase regulates the G2/M cell cycle checkpoint by phosphorylating and inactivating the mitotic cyclin-dependent kinase 1 (Cdk1). Loss of Wee1 in many systems, including yeast and drosophila, leads to premature mitotic entry. However, the developmental role of Wee1 in mammals remains unclear. In this study, we established Wee1 knockout mice by gene targeting. We found that Wee-/- embryos were defective in...

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Identifiers

PMID: 16810330
DOI: 10.7150/ijbs.2.161
PMCID: PMC1483124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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