Article
Drosophila Myt1 is a Cdk1 inhibitory kinase that regulates multiple aspects of cell cycle behavior during gametogenesis.
Development (Cambridge, England) - 1 Sept 2005
Jin Zhigang, Homola Ellen M, Goldbach Philip, Choi Yunhee, Brill Julie A, Campbell Shelagh D
Abstract excerpt
The metazoan Wee1-like kinases Wee1 and Myt1 regulate the essential mitotic regulator Cdk1 by inhibitory phosphorylation. This regulatory mechanism, which prevents Cdk1 from triggering premature mitotic events, is also induced during the DNA damage response and used to coordinate cell proliferation with crucial developmental events. Despite the previously demonstrated role for Myt1 regulation of Cdk1 during...
Topics
- Amino Acid Sequence
- Animals
- CDC2 Protein Kinase
- Cell Cycle
- Cell Proliferation
- Drosophila
- Drosophila Proteins
- Female
- Gametogenesis
- Male
- Microscopy, Fluorescence
- Molecular Sequence Data
- Mutation
- Phenotype