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Article

Disorganization of thymic medulla precedes evolution towards diabetes in female NOD mice.

Autoimmunity - 1 Jan 1999

Atlan-Gepner C, Naspetti M, Valéro R, Barad M, Lepault F, Vialettes B, Naquet P

Abstract excerpt

The thymic medulla is a complex microenvironment which plays a crucial role in central tolerance induction. Using a quantitative histological analysis of non-obese diabetic (NOD) mice, we show that the medulla undergoes several structural modifications during the course of the disease in NOD mice. Indeed, the majority of 70-day-old NOD mice show a scattering of medullary epithelial cells in the cortex which is...

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Source

Identifiers

PMID: 10789990
DOI: 10.3109/08916939908994070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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