Article
Polyubiquitination of the epidermal growth factor receptor occurs at the plasma membrane upon ligand-induced activation.
The Journal of biological chemistry - 5 May 2000
Stang E, Johannessen L E, Knardal S L, Madshus I H
Abstract excerpt
We have previously shown that, although overexpression of mutant dynamin inhibits clathrin-dependent endocytosis and disrupts high affinity binding of epidermal growth factor (EGF) to the EGF receptor (EGFR), it does not inhibit ligand-induced translocation of the EGFR into clathrin-coated pits. In the present study, we demonstrate that, upon ligand binding and incubation at 37 degrees C, the EGFR was...
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