Article
Eps15 is recruited to the plasma membrane upon epidermal growth factor receptor activation and localizes to components of the endocytic pathway during receptor internalization.
Molecular biology of the cell - 1 Feb 1999
Torrisi M R, Lotti L V, Belleudi F, Gradini R, Salcini A E, Confalonieri S, Pelicci P G, Di Fiore P P
Abstract excerpt
Eps15 is a substrate for the tyrosine kinase of the epidermal growth factor receptor (EGFR) and is characterized by the presence of a novel protein:protein interaction domain, the EH domain. Eps15 also stably binds the clathrin adaptor protein complex AP-2. Previous work demonstrated an essential role for eps15 in receptor-mediated endocytosis. In this study we show that, upon activation of the EGFR kinase, eps15...
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