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Article

Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis.

Molecular biology of the cell - 1 Aug 2008

Haugsten Ellen Margrethe, Malecki Jedrzej, Bjørklund Sunniva Maria Stordal, Olsnes Sjur, Wesche Jørgen

Abstract excerpt

Endocytosis and targeting of growth factor receptors for lysosomal degradation have been associated with ubiquitination of the intracellular part of the receptors. To elucidate the role of receptor ubiquitination in internalization and sorting of fibroblast growth factor receptor (FGFR), we constructed several mutants of FGFR1 in which lysines, potential ubiquitination sites, were substituted for arginines....

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Identifiers

PMID: 18480409
DOI: 10.1091/mbc.e07-12-1219
PMCID: PMC2488279

Genes

FGFR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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