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Article

Molecular Pathways of Carcinogenesis in Familial Adenomatous Polyposis

16 Mar 2023

Abstract excerpt

Familial adenomatous polyposis (FAP) is a genetic syndrome characterized by the presence of multiple polyps in the gastrointestinal tract and a wide range of systemic extra-intestinal manifestations. Patients affected will inevitably undergo abdominal surgery due to the malignant transformation of one or more adenomas. The pathogenesis of the disease is based on a loss of function mutation in adenomatous...

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PMID: 36982759
DOI: 10.3390/ijms24065687

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