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Article

IL-15 but not IL-2 rapidly induces lethal xenogeneic graft-versus-host disease

24 Jun 2005

Abstract excerpt

Interleukin-2 (IL-2) and IL-15 are structurally related cytokines that share receptor components but display markedly different effects in multiple in vivo model systems. Here we demonstrate that IL-15 but not IL-2 exacerbates xenogeneic graft-versus-host disease (X-GVHD) in severe combined immunodeficient murine recipients of human peripheral-blood lymphocytes (hu-PBL-SCID). Treatment of hu-PBL-SCID mice with...

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Identifiers

PMID: 15976176
DOI: 10.1182/blood-2005-04-1597

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