Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Uncoupling CD21 and CD19 of the B-cell coreceptor.

Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2009

Barrington Robert A, Schneider Thomas J, Pitcher Lisa A, Mempel Thorsten R, Ma Minghe, Barteneva Natasha S, Carroll Michael C

Abstract excerpt

Complement receptors (CRs) CD21 and CD35 form a coreceptor with CD19 and CD81 on murine B cells that when coligated with the B-cell receptor lowers the threshold of activation by several orders of magnitude. This intrinsic signaling role is thought to explain the impaired humoral immunity of mice bearing deficiency in CRs. However, CRs have additional roles on B cells independent of CD19, such as transport of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibody Formation
Share to Antigens, CD19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Marrow Transplantation

Share to Haptens

Share to Immunization

Share to Immunologic Memory

Share to Receptors, Complement 3b

Share to Receptors, Complement 3d

Source

Open in PubMed Open full text

Identifiers

PMID: 19706534
DOI: 10.1073/pnas.0903477106
PMCID: PMC2732852

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Uncoupling CD21 and CD19 of the B-cell coreceptor.PMID 19706534Read ↗

Deficiencies in the CD19 complex.Semantic proximity Read ↗

Targeting the Immune Complex–Bound Complement C3d Ligand as a Novel Therapy for LupusSemantic proximity Read ↗

Structural requirements for C3d,g/Epstein-Barr virus receptor (CR2/CD21) ligand binding, internalization, and viral infection.Semantic proximity Read ↗

Regulation of B-Cell Activation by Complement Receptors CD21 and CD35Semantic proximity Read ↗

Altered Phenotype and Enhanced Antibody-Producing Ability of Peripheral B Cells in Mice with Cd19-Driven Cre Expression.Semantic proximity Read ↗

Humoral immune responses in Cr2-/- mice: enhanced affinity maturation but impaired antibody persistence.Semantic proximity Read ↗

Human complement receptor type 1/CD35 is an Epstein-Barr Virus receptor.Semantic proximity Read ↗

CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency.Semantic proximity Read ↗

A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses.Semantic proximity Read ↗

Deficiency of the mouse complement regulatory protein mCd59b results in spontaneous hemolytic anemia with platelet activation and progressive male infertility.Semantic proximity Read ↗

B cell activation leads to shedding of complement receptor type II (CR2/CD21)Semantic proximity Read ↗

Defects in the CD19 complex predispose to glomerulonephritis, as well as IgG1 subclass deficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.