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Article

Impaired affinity maturation in Cr2-/- mice is rescued by adjuvants without improvement in germinal center development.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2000

Wu X, Jiang N, Fang Y F, Xu C, Mao D, Singh J, Fu Y X, Molina H

Abstract excerpt

Cr2-/- mice have an impairment in humoral immunity, as shown by the decrease in the Ab titers against T cell-dependent Ags and abnormalities in germinal center formation. Germinal centers are present, but they are decreased in size and number, indicating problems in their development. In this study, we investigated whether this abnormality in germinal center development is associated with problems in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10975825
DOI: 10.4049/jimmunol.165.6.3119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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