Article
Defective B cell ontogeny and humoral immune response in mice prematurely expressing human complement receptor 2 (CR2, CD21) is similar to that seen in aging wild type mice.
Molecular immunology - 1 Jun 2009
Twohig Jason P, Pappworth Isabel Y, Sivasankar Baalasubramanian, Kulik Liudmila, Bull Melanie, Holers V Michael, Wang Eddie C Y, Marchbank Kevin J
Abstract excerpt
Mice prematurely expressing human CR2 (hCR2) in the B cell lineage have a defective B cell ontogeny and humoral immune response. We have previously determined altered tyrosine phosphorylation patterns within hCR2 transgenic mice, suggesting that irreversible changes in B cell signaling pathways had occurred, which could explain the B cell unresponsiveness associated with hCR2 transgene expression. In support of...
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