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Article

A micromethod for quantitation of debrisoquine and 4-hydroxydebrisoquine in urine by liquid chromatography.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 May 2000

Pereira V A, Auler J O, Carmona M J, Mateus F H, Lanchote V L, Breimer D D, Santos S R

Abstract excerpt

We describe a new simple, selective and sensitive micromethod based on HPLC and fluorescence detection to measure debrisoquine (D) and 4-hydroxydebrisoquine (4-OHD) in urine for the investigation of xenobiotic metabolism by debrisoquine hydroxylase (CYP2D6). Four hundred microl of urine was required for the analysis of D and 4-OHD. Peaks were eluted at 8.3 min (4-OHD), 14.0 min (D) and 16.6 min for the internal...

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Identifiers

PMID: 10775881
DOI: 10.1590/s0100-879x2000000500004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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