Article
Characterization of stereoselectivity and genetic polymorphism of the debrisoquine hydroxylation in man via analysis of urinary debrisoquine and 4-hydroxydebrisoquine by capillary electrophoresis.
Electrophoresis - 1 Sept 1997
Lanz M, Theurillat R, Thormann W
Abstract excerpt
Using capillary zone electrophoresis with a phosphate buffer at pH 2.5 containing 50 mM heptakis-(2,3,6-tri-O-methyl)-beta-CD as chiral selector, the separation of the enantiomers of the main metabolite of debrisoquine (DEB), 4-hydroxydebrisoquine (4-OHDEB), is reported. For extraction of underiv...
Topics
- Debrisoquin
- Electrophoresis, Capillary
- Humans
- Hydroxylation
- Male
- Molecular Structure
- Phenotype
- Polymorphism, Genetic
- Stereoisomerism