Article
A signal transduction system that responds to extracellular iron.
Cell - 29 Sept 2000
Wösten M M, Kox L F, Chamnongpol S, Soncini F C, Groisman E A
Abstract excerpt
Iron is essential for all organisms but can be toxic in excess. Iron homeostasis is typically regulated by cytoplasmic iron binding proteins, but here we describe a signal transduction system (PmrA/PmrB) that responds to extracytoplasmic ferric iron. Iron promoted transcription of PmrA-activated...
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