Article
Tumour necrosis factor microsatellites show association with multiple sclerosis.
Journal of the neurological sciences - 20 Mar 1997
Kirk C W, Droogan A G, Hawkins S A, McMillan S A, Nevin N C, Graham C A
Abstract excerpt
The TNF alpha and beta genes are located between the class I and class III HLA loci and have been implicated in the pathogenesis of multiple sclerosis. We carried out allelic association analysis using four microsatellite markers localised within a 20 kb region around the TNF genes. The study was performed on DNA samples from 189 clinically definite MS patients and 206 normal controls, all of Northern Irish...
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