Article
Suppressor genes for malignant and anchorage-independent phenotypes located on human chromosome 9 have no dosage effects.
Cytogenetics and cell genetics - 1 Jan 2000
Islam M Q, Islam K
Abstract excerpt
We have previously shown that microcell-mediated transfer of a der(9)t(X;9) human chromosome (HSA), derived from human fibroblast strain GM0705, into the Syrian hamster cell line BHK-191-5C produced only near-tetraploid hybrids, although the recipient cell line contained a 1:1 ratio of near-diploid and near-tetraploid cells. However, the tumorigenicity and the anchorage independence could be suppressed in the...
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