Article
The defect in the AT-like hamster cell mutants is complemented by mouse chromosome 9 but not by any of the human chromosomes.
Mutation research - 18 Oct 1996
Jongmans W, Verhaegh G W, Jaspers N G, Demant P, Natarajan A T, Shiloh Y, Oshimura M, Stanbridge E J, Athwal R S, Cuthbert A P, Newbold R F, Lohman P H, Zdzienicka M Z
Abstract excerpt
X-ray sensitive Chinese hamster V79 cells mutants, V-C4, V-E5 and V-G8, show an abnormal response to X-ray-induced DNA damage. Like ataxia telangiectasia (AT) cells, they display increased cell killing, chromosomal instability and a diminished inhibition of DNA synthesis following ionizing radiat...
Topics
- Animals
- Ataxia Telangiectasia
- Cell Survival
- Cells, Cultured
- Chromosome Aberrations
- Chromosomes
- Cricetinae
- Dose-Response Relationship, Radiation
- Gamma Rays
- Genetic Complementation Test
- Humans
- Mice
- Mutation
- Radiation Tolerance