Article
The requirement of pax6 for postnatal eye development: evidence from experimental mouse chimeras.
Investigative ophthalmology & visual science - 1 Jul 2007
Li Shengxiu, Goldowitz Dan, Swanson Douglas J
Abstract excerpt
PURPOSE: The small eye mouse mutant (Sey) is caused by a mutation of the Pax6 gene. Previous studies, in which aggregation chimeras were used, have demonstrated that Sey/Sey cells contribute poorly to the neural retina forming small clumps of cells restricted to the inner retina at embryonic day 16.5. In addition, Sey/+ cells are absent from the lens epithelium during this embryonic period and postnatally. This...
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