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Article

The gonadotropin-releasing hormone system does not develop in Small-Eye (Sey) mouse phenotype.

Brain research. Developmental brain research - 15 May 1998

Dellovade T L, Pfaff D W, Schwanzel-Fukuda M

Abstract excerpt

This study examined the development of the gonadotropin releasing-hormone (GnRH) system in a spontaneous mouse mutation, Small-Eye (Sey). This phenotype is due to a point mutation in the developmental control gene Pax-6 and results in failed development of the eye and olfactory placodes in homozygous (Sey/Sey) embryos and a variety of eye abnormalities in heterozygotes (Sey/+). Therefore, Sey/Sey embryos provided...

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Identifiers

PMID: 9593910
DOI: 10.1016/s0165-3806(98)00007-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The gonadotropin-releasing hormone system does not develop in Small-Eye (Sey) mouse phenotype.PMID 9593910Read ↗

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Multiple functions for Pax6 in mouse eye and nasal development.Semantic proximity Read ↗

Use of mutant mouse lines to investigate origin of gonadotropin-releasing hormone-1 neurons: lineage independent of the adenohypophysis.Semantic proximity Read ↗

Altered retinoid signaling in the heads of small eye mouse embryos.Semantic proximity Read ↗

Genetic background effects on dental and other craniofacial abnormalities in homozygous small eye (Pax6Sey/Pax6Sey) mice.Semantic proximity Read ↗

Promoter Transgenics Reveal Multiple Gonadotropin-Releasing Hormone-I-Expressing Cell Populations of Different Embryological Origin in Mouse BrainSemantic proximity Read ↗

Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development.Semantic proximity Read ↗

Increased TSH-producing cells in the pituitary gland of Pax6 haploinsufficient miceSemantic proximity Read ↗

The requirement of pax6 for postnatal eye development: evidence from experimental mouse chimeras.Semantic proximity Read ↗

The small-eye mutation results in abnormalities in the lateral cortical migratory stream.Semantic proximity Read ↗

The transcription factor Pax6 is required for development of the diencephalic dorsal midline secretory radial glia that form the subcommissural organ.Semantic proximity Read ↗

Modifications of the retina neuronal populations of the heterozygous mutant small eye mouse, the Sey(Dey).Semantic proximity Read ↗

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