Article
TP53 mutation-mediated genomic instability induces the evolution of chemoresistance and recurrence in epithelial ovarian cancer.
Diagnostic pathology - 2 Feb 2017
Zhang Meiying, Zhuang Guanglei, Sun Xiangjun, Shen Yanying, Wang Wenjing, Li Qing, Di Wen
Abstract excerpt
BACKGROUND: Genomic instability caused by mutation of the checkpoint molecule TP53 may endow cancer cells with the ability to undergo genomic evolution to survive stress and treatment. We attempted to gain insight into the potential contribution of ovarian cancer genomic instability resulted from TP53 mutation to the aberrant expression of multidrug resistance gene MDR1. METHODS: TP53 mutation status was assessed...
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