Cluster of allele losses within a 2.5 cM region of chromosome 10 in high-grade invasive bladder cancer.

doi:10.1038/sj.onc.1201606

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Article

Cluster of allele losses within a 2.5 cM region of chromosome 10 in high-grade invasive bladder cancer.

Oncogene - 19 Feb 1998

Kagan J, Liu J, Stein J D, Wagner S S, Babkowski R, Grossman B H, Katz R L

Abstract excerpt

A limited number of previous studies have indicated a low frequency of chromosome 10 allele losses and deletions in bladder cancers. We investigated the involvement of chromosome 10 in advanced bladder cancers. Loss of heterozygosity (LOH) was analysed in 19 microsatellite loci in 20 grade III invasive transitional cell carcinomas. Nine (45%) of the 20 tumors had at least one allele loss on the long arm of...

Topics

Aged
Alleles
Carcinoma
Chromosome Deletion
Chromosomes, Human, Pair 10
DNA, Neoplasm
Genetic Linkage
Humans
Loss of Heterozygosity
Male
Microsatellite Repeats
Middle Aged
Urinary Bladder Neoplasms

Source

Open in PubMed

Identifiers

PMID: 9484782
DOI: 10.1038/sj.onc.1201606

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