Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The natural history of acute and chronic thromboembolic disease: the search for the missing link

1 Mar 2000

Abstract excerpt

Thiopurine drugs such as 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) are used to treat acute lymphoblastic leukemia of childhood. To test the hypothesis that variation in the expression of genes within the “thiopurine pathway” might influence 6-MP and 6-TG sensitivity, we generated basal gene expression profiles and IC50 values for both of these thiopurine drugs using a model system consisting of 194 Human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Adenosine and Purinergic Signaling
Share to Autoimmune and Inflammatory Disorders Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10759432
DOI: 10.1034/j.1399-3003.2000.15.01.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The natural history of acute and chronic thromboembolic disease: the search for the missing linkPMID 10759432Read ↗

Ecto-5'-nucleotidase and thiopurine cellular circulation: association with cytotoxicity.Semantic proximity Read ↗

Effects of <i>NT5C2</i> germline variants on 6-mecaptopurine metabolism in children with acute lymphoblastic leukemiaSemantic proximity Read ↗

Interplay between genetics and epigenetics in modulating the risk of venous thromboembolism: A new challenge for personalized therapySemantic proximity Read ↗

Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes.Semantic proximity Read ↗

Effects of NT5C2 Germline Variants on 6-Mecaptopurine Metabolism in Children With Acute Lymphoblastic Leukemia.Semantic proximity Read ↗

Candidate single nucleotide polymorphisms and thromboembolism in acute lymphoblastic leukemia - A NOPHO ALL2008 study.Semantic proximity Read ↗

No praise for folly: genomics will never be useful in arterial thrombosis.Semantic proximity Read ↗

Leukocytosis is a risk factor for thrombosis in essential thrombocythemia: interaction with treatment, standard risk factors, and Jak2 mutation status.Semantic proximity Read ↗

Epigenome editing of human hematopoietic stem cells enables sustained and reversible thrombosis preventionSemantic proximity Read ↗

'MPN Genomic Calculator': real-life use in a young population with essential thrombocythaemia.Semantic proximity Read ↗

Genetics and mechanisms of NT5C2-driven chemotherapy resistance in relapsed ALLSemantic proximity Read ↗

NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.