Article
Leukocytosis is a risk factor for thrombosis in essential thrombocythemia: interaction with treatment, standard risk factors, and Jak2 mutation status.
Blood - 15 Mar 2007
Carobbio Alessandra, Finazzi Guido, Guerini Vittoria, Spinelli Orietta, Delaini Federica, Marchioli Roberto, Borrelli Giovanna, Rambaldi Alessandro, Barbui Tiziano
Abstract excerpt
Leukocytes contribute to the pathogenesis of thrombosis in essential thrombocythemia (ET) through recently discovered mechanisms of activation and interaction with platelets and endothelial cells. To evaluate whether an increased leukocyte count was associated with thrombosis and whether this effect can be modulated by therapy, we analyzed the clinical course of 439 patients with ET followed at the Ospedali...
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