Article

Epigenome editing of human hematopoietic stem cells enables sustained and reversible thrombosis prevention

2026-03-29

Abstract excerpt

Thrombosis remains a major cause of cardiovascular and cerebrovascular diseases, driven in large part by platelet activation and aggregation. Because platelets are continuously produced from hematopoietic stem cells (HSCs), durable reprogramming of HSC output offers a unique opportunity for a one-time antithrombotic intervention. Here, we show that DNA methylation-based epigenome editors delivered transiently as R...

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Literature Corpus work: 314dd4de-dd13-57a7-8a4d-7fd66f8c3e70
DOI: 10.64898/2026.03.27.714536

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