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Article

beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Nov 2005

Ellison David W, Onilude Olabisi E, Lindsey Janet C, Lusher Meryl E, Weston Claire L, Taylor Roger E, Pearson Andrew D, Clifford Steven C

Abstract excerpt

PURPOSE: Identifying pathobiological correlates of clinical behavior or therapeutic response currently represents a key challenge for medulloblastoma research. Nuclear accumulation of the beta-catenin protein is associated with activation of the Wnt/Wg signaling pathway, and mutations affecting components of this pathway have been reported in approximately 15% of sporadic medulloblastomas. We tested the...

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Identifiers

PMID: 16258095
DOI: 10.1200/JCO.2005.01.5479

Genes

APC
CTNNB1
EFS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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