Article
Beta-catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics.
The Journal of pathology - 1 May 2009
Fattet Sarah, Haberler Christine, Legoix Patricia, Varlet Pascale, Lellouch-Tubiana Arielle, Lair Severine, Manie Elodie, Raquin Marie-Anne, Bours Danielle, Carpentier Sabrina, Barillot Emmanuel, Grill Jacques, Doz Francois, Puget Stephanie, Janoueix-Lerosey Isabelle, Delattre Olivier
Abstract excerpt
Medulloblastoma is the most frequent malignant paediatric brain tumour. The activation of the Wnt/beta-catenin pathway occurs in 10-15% of medulloblastomas and has been recently described as a marker for favourable patient outcome. We report a series of 72 paediatric medulloblastomas evaluated for beta-catenin protein expression, CTNNB1 mutations, and comparative genomic hybridization. Gene expression profiles...
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