Article
Frequent mutation and nuclear localization of beta-catenin in anaplastic thyroid carcinoma.
Cancer research - 15 Apr 1999
Garcia-Rostan G, Tallini G, Herrero A, D'Aquila T G, Carcangiu M L, Rimm D L
Abstract excerpt
Beta-catenin is an ubiquitously expressed cytoplasmic protein that has a crucial role in both E-cadherin-mediated cell-cell adhesion and as a downstream signaling molecule in the wingless pathway. Stabilization of beta-catenin followed by nuclear translocation and subsequent T-cell factor/lymphoi...
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