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Article

Response to genetic counseling and testing for the APC I1307K mutation.

American journal of medical genetics - 20 Mar 2000

Johnson K A, Rosenblum-Vos L, Petersen G M, Brensinger J D, Giardiello F M, Griffin C A

Abstract excerpt

The APC I1307K gene mutation is associated with increased colorectal cancer (CRC) risk in Ashkenazi Jews. Factors predicting acceptance of this and other hereditary colon cancer mutation tests in a clinical setting are unknown. We analyzed sex, age, family history, personal history, and gene test results of patients at increased risk for cancer who sought cancer risk counseling at the Johns Hopkins (JH) CRC Risk...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Share to Genes, APC

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Share to Patient Acceptance of Health Care

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Source

Identifiers

PMID: 10756345
DOI: 10.1002/(sici)1096-8628(20000320)91:3<207::aid-ajmg11>3.0.co;2-t

Genes

APC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An update on APC I1307K homozygosity: observations from a large multigene panel testing cohort.Semantic proximity Read ↗

Clinical and screening implications of the I1307K adenomatous polyposis coli gene variant in Israeli Ashkenazi Jews with familial colorectal neoplasia. Evidence for a founder effect.Semantic proximity Read ↗

The APC p.I1307K polymorphism is a significant risk factor for CRC in average risk Ashkenazi Jews.Semantic proximity Read ↗

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