Article
FHIT gene mutations and single nucleotide polymorphism in Indian oral and cervical squamous cell carcinomas.
Oral oncology - 1 Mar 2000
Kannan K, Munirajan A K, Bhuvarahamurthy V, Mohanprasad B K, Shankar P, Tsuchida N, Shanmugam G
Abstract excerpt
Genetic alterations at the FHIT (fragile histidine triad) tumor suppressor gene have been found in various human cancers. We have made an attempt to find point mutations of this gene in two different cancers from India, with entirely different etiologic factors: oral cancer (55 samples) caused by chewing tobacco and cervical cancer (43 samples) caused mainly by HPV (human papilloma virus) infection. Analysis of...
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