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Article

Preferential activity of wild-type and mutant tumor necrosis factor-alpha against tumor-derived endothelial-like cells.

Japanese journal of cancer research : Gann - 1 Jan 2000

Kuroda K, Miyata K, Tsutsumi Y, Tsunoda S, Nishimura K, Mitsuishi Y, Nakagawa S, Mayumi T

Abstract excerpt

Tumor-derived endothelial-like cells (tEC) were prepared by culturing human umbilical vein endothelial cells (HUVEC) in the presence of HT1080 human fibrosarcoma-conditioned medium. tEC showed higher permeability and less cell-adhesion activity than normal HUVEC (nEC). Tumor necrosis factor-alpha (TNF) is known to have tumor-vasculature disrupting activity. tEC showed higher cytotoxicity to recombinant human TNF...

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Source

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Identifiers

PMID: 10744045
DOI: 10.1111/j.1349-7006.2000.tb00860.x
PMCID: PMC5926226

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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