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Article

Targeting antitumor effect of rhTNF-α fusion protein mediated by matrix metalloproteinase-2.

Oncology reports - 1 Feb 2015

Shao Xin, Ren Hui, Wang Yue-Li, Wang Fa, Hou Gan, Huang Di-Nan

Abstract excerpt

The aim of this study was to examine the tumor therapy, targeting effects and side effects of tumor-targeting rhTNF-α fusion protein mediated by matrix metalloproteinase-2 in an animal model in order to provide experimental data for future development of drugs. The median lethal dose (LD50) was obtained from acute toxicity experiments. The A549 lung cancer xenograft model was established, and then randomly...

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Identifiers

PMID: 25421954
DOI: 10.3892/or.2014.3616

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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