Differentiation induction by a tumor-necrosis-factor mutant 471 in human myelogenous leukemic cells via tumor-necrosis-factor receptor-p55.

doi:10.1002/(sici)1097-0215(19981005)78:2<223::aid-ijc17>3.0.co;2-b

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Article

Differentiation induction by a tumor-necrosis-factor mutant 471 in human myelogenous leukemic cells via tumor-necrosis-factor receptor-p55.

International journal of cancer - 5 Oct 1998

Sato T, Watanabe N, Yamauchi N, Sasaki H, Kobayashi D, Tsuji N, Okamoto T, Hagino T, Niitsu Y

Abstract excerpt

The present study examined differentiation-inducing activity by various tumor-necrosis-factor(TNF) mutants against the human leukemic cell lines HL-60 and U-937. Mutant TNF 471, from which 7 N-terminal amino acids of native TNF were deleted and Pro8, Ser9 and Asp10 were replaced by Arg, Lys and A...

Topics

Antigens, CD
Antineoplastic Agents
Cell Differentiation
HL-60 Cells
Humans
Leukemia, Myeloid, Acute
Mutation
Protein Kinase C
Receptors, Tumor Necrosis Factor
Receptors, Tumor Necrosis Factor, Type I
Receptors, Tumor Necrosis Factor, Type II
Signal Transduction
Staurosporine

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transduction, Genetic

Tretinoin

Tumor Cells, Cultured

Tumor Necrosis Factor-alpha

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Identifiers

PMID: 9754656
DOI: 10.1002/(sici)1097-0215(19981005)78:2<223::aid-ijc17>3.0.co;2-b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9754656-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.