Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapamycin and Wortmannin Enhance Replication of a Defective Encephalomyocarditis Virus

1 Jul 1998

Abstract excerpt

Inhibitors of the phosphatidylinositol 3-kinase (PI3 kinase)-FKBP-rapamycin-associated protein (FRAP) pathway, such as rapamycin and wortmannin, induce dephosphorylation and activation of the suppressor of cap-dependent translation, 4E-BP1. Encephalomyocarditis virus (EMCV) infection leads to activation of 4E-BP1 at the time of host translation shutoff. Consistent with these data, rapamycin mildly enhances the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to RNA regulation and disease
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9621041
DOI: 10.1128/jvi.72.7.5811-5819.1998

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapamycin and Wortmannin Enhance Replication of a Defective Encephalomyocarditis VirusPMID 9621041Read ↗

Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus.Semantic proximity Read ↗

Hepatovirus translation requires PDGFA-associated protein 1, an eIF4E-binding protein regulating endoplasmic reticulum stress responsesSemantic proximity Read ↗

Nonstructural proteins 2C and 3D are involved in autophagy as induced by the encephalomyocarditis virusSemantic proximity Read ↗

[The role of the encephalomyocarditis virus type 1 proteins L and 2A in the inhibition of the synthesis of cellular proteins and the accumulation of viral proteins during infection].Semantic proximity Read ↗

Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E PathwaySemantic proximity Read ↗

Involvement of the Interferon-Regulated Antiviral Proteins PKR and RNase L in Reovirus-Induced Shutoff of Cellular TranslationSemantic proximity Read ↗

Encephalomyocarditis viral protein 2A localizes to nucleoli and inhibits cap-dependent mRNA translationSemantic proximity Read ↗

New small-molecule inhibitors effectively blocking picornavirus replication.Semantic proximity Read ↗

Blocking double-stranded RNA-activated protein kinase PKR by Japanese encephalitis virus nonstructural protein 2A.Semantic proximity Read ↗

Targeting cap-dependent translation to inhibit Chikungunya virus replication: selectivity of p38 MAPK inhibitors to virus-infected cells due to autophagy-mediated down regulation of phospho-ERKSemantic proximity Read ↗

A novel approach to recovery of function of mutant proteins by slowing down translation.Semantic proximity Read ↗

The Development of Resistance to an Inhibitor of a Cellular Protein Reveals a critical interaction between the enterovirus protein 2C and a small GTPase Arf1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.