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Article

The antiprion compound 6-aminophenanthridine inhibits the protein folding activity of the ribosome by direct competition.

The Journal of biological chemistry - 28 Jun 2013

Pang Yanhong, Kurella Sriram, Voisset Cécile, Samanta Dibyendu, Banerjee Debapriya, Schabe Ariane, Das Gupta Chanchal, Galons Hervé, Blondel Marc, Sanyal Suparna

Abstract excerpt

Domain V of the 23S/25S/28S rRNA of the large ribosomal subunit constitutes the active center for the protein folding activity of the ribosome (PFAR). Using in vitro transcribed domain V rRNAs from Escherichia coli and Saccharomyces cerevisiae as the folding modulators and human carbonic anhydrase as a model protein, we demonstrate that PFAR is conserved from prokaryotes to eukaryotes. It was shown previously...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23673663
DOI: 10.1074/jbc.M113.466748
PMCID: PMC3696681

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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