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Article

Transmission dynamics of heritable silencing induced by double-stranded RNA in Caenorhabditis elegans.

Genetics - 1 Nov 2008

Alcazar Rosa M, Lin Rueyling, Fire Andrew Z

Abstract excerpt

Heritable silencing effects are gene suppression phenomena that can persist for generations after induction. In the majority of RNAi experiments conducted in Caenorhabditis elegans, the silencing response results in a hypomorphic phenotype where the effects recede after the F1 generation. F2 and subsequent generations revert to the original phenotype. Specific examples of transgenerational RNAi in which effects...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18757930
DOI: 10.1534/genetics.108.089433
PMCID: PMC2581934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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