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Article

Role of gender and genetic variance in plasminogen activator inhibitor-1 secretion from human adipose tissue.

Thrombosis and haemostasis - 1 Feb 2000

van Harmelen V, Wahrenberg H, Eriksson P, Arner P

Abstract excerpt

Gender and the 4G/5G polymorphism in the plasminogen activator inhibitor 1 (PAI-1) gene are believed to play a role in the regulation of plasma PAI-1 activity. Adipose tissue has been found to be an important source of PAI-1. The possible influence of gender and the 4G/5G polymorphism in the PAI-1 gene on PAI-1 secretion from abdominal subcutaneous adipose tissue was investigated in 59 women and 32 men. The...

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Identifiers

PMID: 10739390

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Role of gender and genetic variance in plasminogen activator inhibitor-1 secretion from human adipose tissue.PMID 10739390Read ↗

Role of the 4G/5G polymorphism of PaI-1 gene promoter on PaI-1 levels in obese patients: influence of fat distribution and insulin-resistance.Semantic proximity Read ↗

4G/5G polymorphism modulates PAI-1 circulating levels in obese women.Semantic proximity Read ↗

PAI-1 gene 4G/5G polymorphism, cytokine levels and their relations with metabolic parameters in obese children.Semantic proximity Read ↗

Gender-specific association of the plasminogen activator inhibitor-1 4G/5G polymorphism with central arterial blood pressure.Semantic proximity Read ↗

The gender-specific role of polymorphisms from the fibrinolytic, renin-angiotensin, and bradykinin systems in determining plasma t-PA and PAI-1 levels.Semantic proximity Read ↗

Is the plasminogen activator inhibitor-1 gene a candidate gene predisposing to hypertension? Results from a population-based study in Spain.Semantic proximity Read ↗

Contribution of the type 1 plasminogen activator inhibitor 4G/5G gene polymorphism to impaired fibrinolysis in vital exhaustion.Semantic proximity Read ↗

Allelic frequency of the PAI-1 4G/5G promoter polymorphism in patients with type 2 diabetes mellitus and lack of association with PAI-1 plasma levels.Semantic proximity Read ↗

The common -675 4G/5G polymorphism in the plasminogen activator inhibitor -1 gene is strongly associated with obesity.Semantic proximity Read ↗

The plasminogen activator inhibitor-1 (PAI-1) promoter haplotype is related to PAI-1 plasma concentrations in lean individuals.Semantic proximity Read ↗

The influence of metabolic syndrome components on plasma PAI-1 concentrations is modified by the PAI-1 4G/5G genotype and ethnicity.Semantic proximity Read ↗

Body adiposity but not insulin resistance is associated with -675 4G/5G polymorphism in the PAI-1 gene in a sample of Mexican children.Semantic proximity Read ↗

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