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Article

Is the plasminogen activator inhibitor-1 gene a candidate gene predisposing to hypertension? Results from a population-based study in Spain.

Journal of hypertension - 1 Apr 2007

Martínez-Calatrava María J, González-Sánchez José L, Zabena Carina, Martínez-Larrad María T, Luque-Otero Manuel, Serrano-Ríos Manuel

Abstract excerpt

BACKGROUND: Studies in humans and mice suggest that plasminogen activator inhibitor-1 (PAI-1) might be a candidate gene for arterial hypertension. Our aims were to analyse whether the functional 4G/5G PAI-1 polymorphism represents a risk marker for the development of arterial hypertension regardless of hypertension-related metabolic variables. METHODS: Eight hundred and fifteen unrelated individuals (387 men, age...

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PMID: 17351368
DOI: 10.1097/HJH.0b013e32803cae09

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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