Article
Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients.
Oncogene - 3 Jul 2003
Crabtree Michael, Sieber Oliver M, Lipton Lara, Hodgson Shirley V, Lamlum Hanan, Thomas Hunu J W, Neale Kay, Phillips Robin K S, Heinimann Karl, Tomlinson Ian P M
Abstract excerpt
The site of the 'first hit' in the APC tumour suppressor gene determines the type of the 'second hit', both in familial adenomatous polyposis (FAP) and sporadic colorectal tumours. Mutations near codon 1300 are associated with loss of heterozygosity (LOH) of the wild-type allele; other tumours te...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.