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APC Mutations Are Not Confined to Hotspot Regions in Early-Onset Colorectal Cancer

18 Dec 2020

Abstract excerpt

While overall colorectal cancer (CRC) cases have been declining worldwide there has been an increase in the incidence of the disease among patients under 50 years of age. Mutation of the APC gene is a common early event in CRC but is reported at lower rates in early-onset colorectal cancer (EOCRC) than in older patients. Here we investigate the APC mutation status of a cohort of EOCRC patients in New Zealand...

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PMID: 33352971
DOI: 10.3390/cancers12123829

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