Article
Different combinations of biallelic APC mutation confer different growth advantages in colorectal tumours.
Cancer research - 15 Jan 2002
Cheadle Jeremy P, Krawczak Michael, Thomas Meinir W, Hodges Angela K, Al-Tassan Nada, Fleming Nick, Sampson Julian R
Abstract excerpt
New facets to Knudson's [corrected] "two-hit" hypothesis have been proposed recently in relation to adenomatous polyposis coli (APC): protein inactivation may be selected weakly, and the two hits may be interdependent. We reviewed published data on 165 sporadic and 102 familial adenomatous polyposis-associated colorectal tumors with two characterized mutations. Using a Poisson model, we redefined the mutation...
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