Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diverse effects of 9-hydroxyellipticine on the chemosensitivity of human pancreatic cancer cells harboring p53 mutations.

Cancer letters - 28 Feb 2000

Mizumoto K, Sato N, Kusumoto M, Niiyama H, Maehara N, Nishio S, Li Z, Ogawa T, Tanaka M

Abstract excerpt

Recently, it has been shown that 9-hydroxyellipticine (9-HE), an antitumor alkaloid has a unique property of restoring functional wild-type (wt) p53 activity via inhibition of mutant (mt) p53 protein phosphorylation. In the present study, we investigated the effect of 9-HE on the drug sensitivity of human pancreatic cancer cells. Exposure of cells to 9-HE at a relatively low concentration of 1 microM induced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimetabolites, Antineoplastic
Share to Antineoplastic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Interactions

Share to Drug Monitoring

Share to Mutation

Share to Pancreatic Neoplasms

Share to Tumor Cells, Cultured

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 10737712
DOI: 10.1016/s0304-3835(99)00345-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diverse effects of 9-hydroxyellipticine on the chemosensitivity of human pancreatic cancer cells harboring p53 mutations.PMID 10737712Read ↗

Inhibition of p53 Protein Phosphorylation by 9‐Hydroxyellipticine: A Possible Anticancer MechanismSemantic proximity Read ↗

Mutant p53 mediated induction of cell cycle arrest and apoptosis at G1 phase by 9-hydroxyellipticine.Semantic proximity Read ↗

[6]-Gingerol induces cell cycle arrest and cell death of mutant p53-expressing pancreatic cancer cells.Semantic proximity Read ↗

Expression of a non-functional p53 affects the sensitivity of cancer cells to gemcitabine.Semantic proximity Read ↗

Rescue of mutant p53 transcription function by ellipticine.Semantic proximity Read ↗

Apoptosis Induction by 3EE, 20Ac-Ingenol in p53- and K-RAS-Mutated Pancreatic Cancer, Panc-1 Cells Overexpressing Cyclin D1 Through Cdk2/E2F1 and ARF ActivationSemantic proximity Read ↗

Ellipticine cytotoxicity to cancer cell lines - a comparative studySemantic proximity Read ↗

p53 and p21 determine the sensitivity of noscapine-induced apoptosis in colon cancer cells.Semantic proximity Read ↗

Enhancement of gemcitabine-induced apoptosis by restoration of p53 function in human pancreatic tumors.Semantic proximity Read ↗

The mutational status of p53 protein in gastric and esophageal adenocarcinoma cell lines predicts sensitivity to chemotherapeutic agentsSemantic proximity Read ↗

Antitumor effect of novel small chemical inhibitors of Snail-p53 binding in K-Ras-mutated cancer cells.Semantic proximity Read ↗

Nobiletin induces apoptosis and potentiates the effects of the anticancer drug 5-fluorouracil in p53-mutated SNU-16 human gastric cancer cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.