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Apoptosis Induction by 3EE, 20Ac-Ingenol in p53- and K-RAS-Mutated Pancreatic Cancer, Panc-1 Cells Overexpressing Cyclin D1 Through Cdk2/E2F1 and ARF Activation

2026-07-02

Abstract excerpt

The tumor suppressor gene p53 plays a central role in tumor suppression and is the most frequently mutated gene in human cancers; p53 mutation is most often associated with reduction or loss of function of the protein. BALL-1 and Panc-1 cells harbor p53 mutations and overexpress cyclin D1, making them resistant to drugs that induce p53-dependent apoptosis. 3EE, 20Ac-ingenol activates p53 in these cells via ATR/ATM...

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Literature Corpus work: ff1e71d4-bb25-54de-9477-b9e0d96c3569
DOI: 10.20944/preprints202607.0151.v1

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Apoptosis Induction by 3EE, 20Ac-Ingenol in p53- and K-RAS-Mutated Pancreatic Cancer, Panc-1 Cells Overexpressing Cyclin D1 Through Cdk2/E2F1 and ARF ActivationDOI 10.20944/preprints202607.0151.v1Read

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