Enhancement of gemcitabine-induced apoptosis by restoration of p53 function in human pancreatic tumors.

doi:10.1159/000086772

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Article

Enhancement of gemcitabine-induced apoptosis by restoration of p53 function in human pancreatic tumors.

Oncology - 1 Jan 2005

Cascalló Manel, Calbó Joaquim, Capellà Gabriel, Fillat Cristina, Pastor-Anglada Marçal, Mazo Adela

Abstract excerpt

Human pancreatic adenocarcinomas are highly resistant to conventional treatment modalities, specially to chemotherapy. Among the genes that modulate apoptosis in response to cytotoxic drugs, the role of p53 has been demonstrated to be of paramount importance. Moreover, p53 is mutated in close to 50% of pancreatic cancer, which renders attractive the reintroduction of this gene as a way to enhance the action of...

Topics

Adenocarcinoma
Animals
Antimetabolites, Antineoplastic
Apoptosis
Colorimetry
Deoxycytidine
Drug Administration Schedule
Humans
In Situ Nick-End Labeling
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Mice, Nude

Mutation

Pancreatic Neoplasms

Transplantation, Heterologous

Tumor Suppressor Protein p53

beta-Galactosidase

Source

Open in PubMed

Identifiers

PMID: 16006755
DOI: 10.1159/000086772

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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