Article
The effect of cellular environment and p53 status on the mode of action of the platinum derivative LA-12.
Investigational new drugs - 1 Aug 2010
Roubalová Eva, Kvardová Veronika, Hrstka Roman, Borilová Sárka, Michalová Eva, Dubská Lenka, Müller Petr, Sova Petr, Vojtesek Borivoj
Abstract excerpt
In this study, we characterized the effects of LA-12 on tumor cell lines possessing wild type p53 and on p53-deficient/mutant cell lines and the results were compared to those obtained using cisplatin. We have determined changes of p53 levels, of its transcriptional activity, of its posttranscriptional modifications and the effect of the treatment on the cell cycle, on the induction of apoptosis and on gene...
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