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Article

p53 and p21 determine the sensitivity of noscapine-induced apoptosis in colon cancer cells.

Cancer research - 15 Apr 2007

Aneja Ritu, Ghaleb Amr M, Zhou Jun, Yang Vincent W, Joshi Harish C

Abstract excerpt

We have previously discovered the naturally occurring antitussive alkaloid noscapine as a tubulin-binding agent that attenuates microtubule dynamics and arrests mammalian cells at mitosis via activation of the c-Jun NH(2)-terminal kinase pathway. It is well established that the p53 protein plays...

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Identifiers

PMID: 17440101
DOI: 10.1158/0008-5472.CAN-06-4282
PMCID: PMC3757339

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BAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17440101-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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