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Article

Inhibition of p53 Protein Phosphorylation by 9‐Hydroxyellipticine: A Possible Anticancer Mechanism

1 Sept 1995

Abstract excerpt

Abnormality of p53, a tumor suppressor gene, is considered to be a potential cause of malignancy. We found that ellipticine and 9-hydroxyellipticine (9HE), antitumor alkaloids, caused selective inhibition of p53 protein phosphorylation in Lewis lung carcinoma and SW480 (human colon cancer cell line) in a concentration-dependent manner from 0.1 to 100 microM. 9HE suppressed cdk2 kinase activity...

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PMID: 7591958
DOI: 10.1111/j.1349-7006.1995.tb03091.x

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Inhibition of p53 Protein Phosphorylation by 9‐Hydroxyellipticine: A Possible Anticancer MechanismPMID 7591958Read ↗

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