[6]-Gingerol induces cell cycle arrest and cell death of mutant p53-expressing pancreatic cancer cells.

Abstract excerpt

[6]-Gingerol, a major phenolic compound derived from ginger, has anti-bacterial, anti-inflammatory and anti-tumor activities. While several molecular mechanisms have been described to underlie its effects on cells in vitro and in vivo, the underlying mechanisms by which [6]-gingerol exerts anti-tumorigenic effects are largely unknown. The purpose of this study was to investigate the action of [6]-gingerol on two...

Topics

• Antineoplastic Agents
• Apoptosis
• Catechols
• Cell Cycle
• Cell Line, Tumor
• Cell Proliferation
• Drug Resistance, Neoplasm
• Fatty Alcohols
• Gene Expression Regulation, Neoplastic
• Humans
• Mutation