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Article

Ellipticine cytotoxicity to cancer cell lines - a comparative study

1 Jan 2011

Abstract excerpt

Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of action. This anticancer agent should be considered a pro-drug, whose pharmacological efficiency and/or genotoxic side effects are dependent on its cytochrome P450 (CYP)- and/or peroxidase-mediated activation to species forming covalent DNA adducts. Ellipticine can also act as an inhibitor or inducer of biotransformation enzymes,...

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PMID: 21753906
DOI: 10.2478/v10102-011-0017-7

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