Article
Lower cognitive performance in normal older adult male twins carrying the apolipoprotein E epsilon 4 allele.
Archives of neurology - 1 Dec 1994
Reed T, Carmelli D, Swan G E, Breitner J C, Welsh K A, Jarvik G P, Deeb S, Auwerx J
Abstract excerpt
OBJECTIVE: Given the strong association of the apolipoprotein E (apoE) allele epsilon 4 with late-onset Alzheimer dementia or multi-infarct dementia, we tested whether normal older adult men with at least one epsilon 4 allele demonstrate subclinical changes in cognition and perform more poorly on tests of cognitive function compared with subjects without the epsilon 4 allele. DESIGN: Matched-pair design of normal...
Topics
- Alleles
- Alzheimer Disease
- Apolipoproteins E
- Cognition
- Cognition Disorders
- Dementia, Multi-Infarct
- Diseases in Twins
- Humans
- Male
- Middle Aged
- Neuropsychological Tests