Article
Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.
Cell - 25 Mar 1994
Heusel J W, Wesselschmidt R L, Shresta S, Russell J H, Ley T J
Abstract excerpt
We have generated H-2b mice with a homozygous null mutation in the granzyme (gzm) B gene. Gzm B is a neutral serine protease with Aspase activity that is found only in the granules of activated cytolytic T cells, natural killer cells, and lymphokine-activated killer cells. Gzm B-/- mice develop n...
Topics
- Animals
- Apoptosis
- DNA
- Embryo, Mammalian
- Granzymes
- Hematopoiesis
- Killer Cells, Natural
- Lymphocyte Activation
- Lymphocyte Culture Test, Mixed
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Multigene Family
- Mutation
- Serine Endopeptidases
- Stem Cells
- T-Lymphocytes, Cytotoxic